Find out what a flight from Des Moines to Knoxville might cost

Prices vary based on date, airline, and availability. Compare several options if you're flying between Des Moines and Knoxville.

Select your dates to check current offers.

Try shifting your departure forward or backward by a day to find better options. If you’re looking for a good deal, consider flying outside peak hours as well.

Which airports serve Des Moines and Knoxville?

When planning a trip of about 1052 km, it's a good idea to check flights from surrounding airports too.

• Airports in Des Moines: Des Moines is the only operational airport in the area.
• Airports in Knoxville: The only active airport in Knoxville is Knoxville - McGhee Tyson.

The closest airport isn’t always the cheapest — it’s worth checking the alternatives too. In some cities, smaller airports offer lower fares than the main ones.

Plan smarter: flights from Des Moines to Knoxville

Find the flight that fits your plans with Jetcost. You can filter results by stops, agencies, budget, time of day, and airline — all in one search.

Other popular destinations

Travelers flying to United States also checked out: Las Vegas, Los Angeles, Miami, New York City, Orlando.

Comparing offers from multiple agencies helps you find the best price for the same route. You can also spot exclusive deals from individual airlines right in the results list.